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pentobarbital will minimize the extent or impact of amlodipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.Contraindicated (one)pentobarbital decreases levels of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Solid CYP3A4 inducers can cut down panobinostat ranges by ~70% and